Lots of good suggestions here. Kristin Chenoweth feels more like a Louise than Mary to me.
Hargitay would be stellar, and I hope she does more theater in general.
Sherie Rene Scott is my top choice in the category of people who probably aren't famous enough to get the gig.
Samantha Morton is someone who could fit the Betty Gilpin mode of straddling between unhinged comedy and playing it deadly serious.
My blue-sky wishes would be Da'Vine Joy Randolph, Parker Posey or Amanda Seyfried.
"You travel alone because other people are only there to remind you how much that hook hurts that we all bit down on. Wait for that one day we can bite free and get back out there in space where we belong, sail back over water, over skies, into space, the hook finally out of our mouths and we wander back out there in space spawning to other planets never to return hurrah to earth and we'll look back and can't even see these lives here anymore. Only the taste of blood to remind us we ever existed. The earth is small. We're gone. We're dead. We're safe."
-John Guare, Landscape of the Body